General Cell Based Assays
Meso Scale Discovery U-PLEX Mouse TNF- ASY
The Meso Scale Discovery U-PLEX Mouse TNF-alpha Assay is a multiplex immunoassay kit that enables simultaneous measurement of mouse tumor necrosis factor alpha (TNF-alpha) in serum plasma and cell culture supernatants It utilizes electrochemiluminescence (ECL) detection technology and provides high sensitivity broad dynamic range and intra- and inter-assay precision This assay requires 50 L or less sample volume and can be fully automated on the MSD instrument platforms The lower limit of detection is 0 04 pg/mL
Genscript Corporation ToxinSensor Single Tests Kit
GenScript ToxinSensor Single Tests Kit with Standard is designed to be a qualitative In Vitro end-point endotoxin test for human and animal parenteral drugs biological products and medical devices Tachypleus Amebocyte Lysate (TAL) as supplied is to be reconstituted with sample or control directly After incubation for 1 hour and in the presence of endotoxin gelation occurs in the absence of endotoxin gelation does not occur GenScript supply a series of ToxinSensorTM Single Tests Kits with Standard with different sensitivity (0 03 EU/ml 0 06 EU/ml 0 125 EU/ml and 0 25 EU/ml)
Eurofins Discoverx PathHunter eXpress HTR2C (VNV) U2OS β-Arrestin GPCR Assay, 2pl Kit. (93-0938E3CP19M)
The PathHunter HTR2C(VNV) eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. serotonin) based activation of HTR2C(VNV) GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged HTR2C(VNV) and EA-tagged β-Arrestin-2. Activation of HTR2C(VNV) stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress CXCR2 Activated GPCR Internalization Assay, 10pl Kit. (93-0934E3CP5L)
The PathHunter CXCR2 Activated GPCR internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit uses EFC technology to measure ligand-induced internalization of CXCR2 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged CXCR2. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting CXCR2-arrestin complex is internalized to the early endosome, leading to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress PTGFR U2OS β-Arrestin GPCR Assay, 2-Plate Kit. (93-0936E3CP5M)
The PathHunter PTGFR eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. cloprostenol) based activation of PTGFR GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged PTGFR and EA-tagged β-Arrestin-2. Activation of PTGFR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter Darbepoetin Alfa Bioassay Kit, 2pl. (93-0965Y3-00019)
The PathHunter Darbepoetin Alfa Bioassay kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses erythropoetin or darbepoetin alfa-induced dimerization of EPOR receptors. This product uses EFC technology. The cell line included overexpresses EPOR target protein fused to PK alongside EPOR target protein fused to EA. Upon ligand-induced dimerization of EPOR, detectable EFC signal is produced. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates. For detailed product information, User manual and COA, visit www.discoverx.com/bioassay.
Eurofins Discoverx PathHunter eXpress P2RY1 U2OS β-Arrestin GPCR Assay, 10-Plate Kit. (93-0941E3CP5L)
The PathHunter P2RY1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. ATP) based activation of P2RY1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged P2RY1 and EA-tagged β-Arrestin-2. Activation of P2RY1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress MCHR1 U2OS β-Arrestin GPCR Assay, 10-Plate Kit. (93-0940E3CP5L)
The PathHunter MCHR1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. MCH) based activation of MCHR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged MCHR1 and EA-tagged β-Arrestin-2. Activation of MCHR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress MCHR1 U2OS β-Arrestin GPCR Assay, 2-Plate Kit. (93-0940E3CP5M)
The PathHunter MCHR1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. MCH) based activation of MCHR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged MCHR1 and EA-tagged β-Arrestin-2. Activation of MCHR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter Bioassay Detection Kit, 500 (10,000 dp, 96-well). (93-0933L)
The PathHunter Bioassay Detection Kit is a detection kit intended for use with Eurofins DiscoverX's PathHunter Bioassay cells or cell lines. This kit contains lysis buffer and EFC substrate to allow for detection of EFC levels in the assayed cells. This kit contains all components required to assay 100 plates (96-well). For detailed product information, User manual and COA, visit www.discoverx.com/products/reagents/detection-kit-93-0933l.
Eurofins Discoverx PathHunter eXpress HTR2C (VNV) U2OS β-Arrestin GPCR Assay, 10pl Kit. (93-0938E3CP19L)
The PathHunter HTR2C(VNV) eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. serotonin) based activation of HTR2C(VNV) GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged HTR2C(VNV) and EA-tagged β-Arrestin-2. Activation of HTR2C(VNV) stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.